Serum Concentration Following the Oral Administration of Crystalline Procaine Penicillin G and Crystalline Sodium Penicillin G*

Variations in serum concentrations of penicillin after injections of aqueous procaine penicillin G with and without oral probenecid.

Probenecid by inhibiting the renal excretion of penicillin raises its serum level (Boger, Beatty, Pitts, and Flippin, 1950; Burnell and Kirby, 1951; Meads, Knight, and Izlar, 1951; Frisk, Diding, and Wallmark, 1952), a pharmacological effect of which increasing use has been made in the treatment of gonorrhoea (Hilton, 1959; Jensen, Kvorning, and N0rredam, 1963; Holmes, Johnson, and Floyd, 1967;...

Urinary tract infection and oral penicillin G.

The urinary excretion of three oral preparations of penicillin G was measured in six subjects. After a dose of 500 mg of potassium penicillin G the mean urine level was 597 mug/ml in the first of three two-hour periods, 324 mug/ml in the second, and 40 mug/ml between the fourth and sixth hours. Of the dose, 13.4% was excreted in the urine in 24 hours. Differences among the three preparations we...

Penicillin Failures in Gonorrhoea: Responses to Procaine Benzyl Penicillin G and to Ampicillin.

There is considerable evidence of increasing failure rates following the treatment of gonorrhoea with penicillin (Mead, Moon, and Bean, 1960; Willcox, 1961; Sabath and Kivlahan, 1961). Doses and preparations of penicillin sufficient a decade ago have become no longer so in many areas. The reasons for failure are manifold and complex. They include re-infection, which is probably common but extre...

Interaction among Nystatin and Penicillin G against Saccharomyces cerevisiae

SERUM PENICILLIN LEVEL A FTER INTRAMUSCULA R INJECTION OF 1,200,000 UNITS OF BENZATHINE PENICILLIN G IN CHILDREN WITH RHEUMATIC FEVER

The most accepted method of secondary prophylaxis in rheumatic fever (RF) has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. The WHO recommended BPG injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of on...